AORTIC VALVE
TAVR
A bioprosthetic valve frame positioned within the native aortic annulus.
Structural heart R&D
Designing the next era of transcatheter care.
Physician-informed research and development focused on structural heart valve technologies, catheter-based therapies, and elegant solutions for complex anatomy.
R&D
Aortic
Valve
Valve
Mitral
Valve
Valve
Tricuspid
Valve
Valve
LAA &
Septal
Septal
Visual technology atlas
Anatomy and representative implant concepts.
Explore the target anatomy and the general form of catheter-based technologies used across contemporary structural heart care.
LEFT ATRIAL APPENDAGE
LAA Occlusion
A conformable occlusion implant seated at the appendage ostium.
ATRIAL SEPTUM
ASD & PFO Closure
Disc-based occlusion and tissue-preserving suture closure concepts.
MITRAL VALVE
Mitral Therapies
Leaflet approximation and transcatheter replacement concepts for mitral disease.
TRICUSPID VALVE
Tricuspid Therapies
Catheter-based repair and replacement concepts designed for right-heart anatomy.
Educational illustrations are generic and are not depictions of any specific manufacturer’s product. Device selection and treatment decisions require evaluation by a qualified heart team.
Technology platforms
Innovation across the structural heart continuum.
Our focus spans valve replacement, repair, occlusion, and closure systems—grounded in anatomy, procedural reality, and meaningful clinical need.
Transcatheter Aortic Valve Replacement
Concepts for valve performance, anchoring, sealing, commissural alignment, coronary access, delivery systems, and lifetime management.
Left Atrial Appendage Occlusion
Approaches to adaptable fixation, complete sealing, lower device footprint, procedural simplicity, and anatomy-responsive closure.
Atrial Septal Technologies
Transcatheter and suture-based concepts for ASD and PFO closure with attention to tissue preservation and future access.
Transcatheter Mitral Technologies
Replacement and repair concepts addressing annular complexity, LVOT interaction, sealing, anchoring, and deliverability.
Transcatheter Tricuspid Technologies
Systems designed around large, dynamic anatomy, variable leaflet geometry, right-heart physiology, and venous access.
Development approach
From unmet need to testable concept.
A disciplined pathway links clinical insight to engineering development while keeping usability, anatomy, and safety at the center.
01
Define the need
Identify a consequential clinical or procedural limitation worth solving.
02
Design around anatomy
Translate imaging, biomechanics, and procedural constraints into requirements.
03
Prototype & iterate
Develop concepts, assess failure modes, and refine through structured testing.
04
Build the evidence path
Prepare for verification, preclinical evaluation, regulatory strategy, and translation.
HF
Human factors begin at the first sketch.
Delivery, visualization, deployment, repositioning, retrieval, and workflow should be designed as one integrated clinical experience—not addressed after the device is built.
Core capabilities
Clinical insight translated into engineering direction.
Structural Heart Innovations brings a procedural lens to early-stage device strategy, concept definition, and development planning.
01
Clinical needs assessment
Procedural pain points, patient selection gaps, anatomical limitations, workflow friction, and complication-driven opportunities.
02
Concept and design input
Physician-led product requirements, delivery concepts, deployment sequences, and usability priorities.
03
Imaging and anatomical strategy
CT, echocardiographic, fluoroscopic, and access considerations integrated into device architecture.
04
Translational planning
Bench-test logic, preclinical questions, risk framing, clinical endpoints, and development milestones.
05
Strategic collaboration
Engagement with engineers, inventors, research partners, manufacturers, and development teams.
Physician-founder
Innovation shaped by the realities of the procedure room.
Dr. Raj Marok is a board-certified interventional and structural cardiologist with more than a decade of experience in complex coronary intervention, transcatheter valve therapy, left atrial appendage closure, and congenital structural interventions. A Clovis native, he returned to California’s Central Valley after serving as Medical Director of Structural Heart Disease and Co-Director of a complex high-risk PCI and CTO program in West Michigan.
He previously served as an Associate Professor of Medicine at Michigan State University College of Human Medicine and as core faculty for an interventional cardiology fellowship. His advanced interventional training included structural heart, complex coronary, and vascular intervention at Columbia University Medical Center and NewYork-Presbyterian Hospital.
Dr. Marok’s research and development interests center on left atrial appendage closure, transcatheter valve technologies, imaging-guided intervention, and quality improvement. He has served as a principal investigator and sub-investigator in multicenter clinical trials and participated in the world’s first preclinical implant of the WATCHMAN FLX Pro device as part of its FDA approval program.
Structural heart leadershipProgram development, clinical operations, and quality improvement
Academic medicineFormer Associate Professor and fellowship core faculty
Clinical researchPrincipal investigator across LAA closure and structural studies
Advanced trainingColumbia University and NewYork-Presbyterian Hospital
His work is driven by a simple premise: device design should begin with anatomy, workflow, and the unmet needs encountered in real patient care.
For patients & families
Connect with our team.
If you are interested in learning about our research focus, sharing a patient perspective, or receiving future updates, send us a brief message.
- Learn about our areas of research
- Share the patient or caregiver perspective
- Ask about future educational updates
Structural Heart Innovations
Better devices begin with better questions.
We are developing and evaluating new ideas at the intersection of structural heart medicine, device engineering, and procedural innovation.
structuralheartinnovations@gmail.com ↗Research & development · Clovis, California